Can I Use an AI & SERM Together?

Almost all need T+hCG+AI.

SERMs increase E2, many get that wrong.

You should be near E2=80 pmol/L

If SERM dose is too high, or too high for you, too much LH leads to high testicular T–>E2 and serum E2 gets high. Anastrozole can fail to help because it really only can work on T–>E2 in peripheral tissues and not inside the testes. SERMs are not always viable.

We need details of your protocol. Are you on a SERM?

Directly edit your post above, look for pencil icon and add lab ranges. Also add any other lab data that you have. Do not skip because it states normal.

Low SHBG sometimes just happens. But there is an association with diabetes. So we have interest in fasting glucose and A1C.

SERMs do not have any direct effect on SHBG! More E2 would but E2 already is too high.

What other health issues and medications?

Is fertility a concern?

Suggest .5mg anastrozole 3 times per week.
Should notice changes in 5-7 days.
If you feel crashed in 2-3 days or sooner, stop and then resume after 6 days at 1/4th of the above dosing. So .25 or .2mg twice a week would be a good re-attempt.

If E2 levels do not come down near E2=80pmol/L target, the problem is the SERM with LH too high. You can test LH/FSH on a SERM to see what is happening. An acceptable SERM dose from an E2 point of view might not be able to sustain good T levels. So a SERM sometimes?often does not work.


Please read the stickies found here: About the T Replacement Category - #2 by KSman

  • advice for new guys - need more info about you
  • things that damage your hormones
  • protocol for injections
  • finding a TRT doc

Evaluate your overall thyroid function by checking oral body temperatures as per the thyroid basics sticky. Thyroid hormone fT3 is what gets the job done and it regulates mitochondrial activity, the source of ATP which is the universal currency of cellular energy. This is part of the body’s temperature control loop. This can get messed up if you are iodine deficient. In many countries, you need to be using iodized salt. Other countries add iodine to dairy or bread.

KSman is simply a regular member on this site. Nothing more other than highly active.

I can be a bit abrupt in my replies and recommendations. I have a lot of ground to cover as this forum has become much more active in the last two years. I can’t follow threads that go deep over time. You need to respond to all of my points and requests as soon as possible before you fall off of my radar. The worse problems are guys who ignore issues re thyroid, body temperatures, history of iodized salt. Please do not piss people off saying that lab results are normal, we need lab number and ranges.

The value that you get out of this process and forum depends on your effort and performance. The bulk of your learning is reading/studying the suggested stickies.