You are probably not having Arimidex/anastrozole side effects, but have problems with E2 levels getting too low because anastrozole dose was not right for you.
Anastrozole is a competitive drug, with testosterone, at aromatase reaction sites where FT–>E2 happens and that reaction rate is modulated. For this to work properly, serum anastrozole levels need to match serum FT/Bio-T levels.
Injecting T once a week is most often not frequent enough:
- T levels rise and fall a lot
- Anastrozole dose is too high as T drops
We need FT lab results and ranges. If SHBG is elevated, T+SHBG is elevated and non-bioavailable and that can inflate TT levels.
We do not see that 60mg T cyp/eth is effective at relieving symptoms of low T.
Suggest:
- 50mg T cyp twice a week
- 0.5mg anastrozole at same time
- 500 iu hCG at same time
Inability to absorb transdermal T is often a sign if low thyroid function. You can check your overall thyroid function by checking oral body temperatures as per the thyroid basics sticky. You can have thyroid problems if not using iodized salt and/or vitamins that list iodine+selenium.
You can dissolve anastrozole in vodka, 1mg/ml and dispense by volume with a syringe or by the drop after counting drops per ml with a dropper bottle.
Most need a lot of Vit-D3. Suggest 5000iu - find tiny oil based capsules. Later you can test Vit-D25 levels. Vit-D25 is an active hormone essential for many aspects of proper gene expression in your cells. In your case, 10,000iu could be tried to see if you improve.
Please post labs and ranges in list format:
TT
FT
E2
RBC
hematocrit
serum protein
albumin
AST/ALT
prolactin
TSH
fT3
fT4
CRP
fasting glucose
fasting cholesterol - can be too low
AM cortisol
IGF-1
Were LH/FSH low before TRT?
Blows to the head?
It well known, but few know, that when TRT increases/restores metabolic demands that one can feel worse if thyroid and/or adrenals cannot keep up, one can feel worse. Even if thyroid fT3 is ideal, the active hormone, one can be in trouble if reverse T3 - rT3 is blocking fT3 from working.
rT3 can be elevated from adrenal fatigue and the factors are:
- acute or chronic illnesses
- chronic inflammation, infections or allergies
- daily stress or major stress events
- stimulant/caffeine abuse
- driving through difficulties or weaknesses with will power and adrenalin
- see the thyroid basics sticky
Thyroid fT3 controls your energy levels by regulation of mitochondria inside your cells as part of the control loop that regulates body temperature. Mitochondria make ATP, the universal currency of cellular energy.
Please see these stickies found here: About the T Replacement Category - #2 by KSman
- advice for new guys
- things that damage your hormones
- protocol for injections
- thyroid basics
Arthritis: This is characterized by a cycle of persistent inflammation that damages joint tissues. It can come out of the blue. It is important to stop the process and naproxen etc does not work well. Ask for a Rx of 15mg meloxicam. You take it once a day and it can be very effective and is a very small drug load on your body. You can get a years supply for $40 at USA Walmart. It is the only thing that really got my hands under control. Pain and inflammation/redness resolved and a lot of joint swelling cleared up. So the cycle of inflammation and destruction was ended [for me].
Please work on all of the issues presented above.
Tired: Are you getting good sleep or lying awake. Do you take any sleep aids now?
Do body temperatures ASAP, the results can be very informative.
??train conductor for Canadian Pacific??