Best Way to Raise SHBG?

Pharma TRT
21

A good R2 tells you that the assay has good linearity and presumably good precision, but it doesn’t tell anything about accuracy.
All the values could be associated with a systematic bias (bad accuracy) and you would still be getting a good correlation.

If you are lucky and have ‚the correct‘ SHBG level (not knowing what the level is) for the test it could indeed reflect your true freeT levels, but keep in mind that SHBG levels typically change on TRT. If not a bias is introduced as the assay apparently measures a constant fraction of total T independent of SHBG levels. This is also reflected in the very different concentration levels the assay reports.

Fritz et al approached the assay in a very systematic way. Very interesting read. I hope it’s freely accessible.
https://academic.oup.com/clinchem/article/54/3/512/5628433

2 Likes
22

Metformin will raise your shbg . It will also make you more sensible to insulin. I love that drug but I had to stop it as I already have a sky high shbg baseline. I would take it forever.

23

I dose at 200mg once a week. Have been taking 1/2 a mg of Anastrozole. Stopped that last week to see how I feel.

Tried dosing at 100mg twice weekly, but after a couple of months, noticed no difference in mood, energy, etc…As a matter of fact, I actually noticed a decline in libido if anything.

Been considering backing off to maybe 150mg a week and see how that makes me feel. AFter 2 1/2 years on TRT, Ive actually never had the “this stuff is great!!” feeling that most have.

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You do know anastrozole lowers shbg right?

25

whats so great about it?

26

You will live longer. Check it.