Ask Physiolojik Thread

I can’t take amphetamines… I do (prescribed) to help me study (ADD, diagnosed at a very young age), however I’m insanely sensitive. I took 10mg dexamfetamine today, took my RHR from like 55 to 85! As to be expected, alcohol does the same, but lowers my inhibitions significantly and reduces anxiety so I don’t care/notice

Can relate, however it wasn’t working out that triggered such high rates (aside from say… sprinting), it was more related to going from sitting to standing suddenly. On amphetamines today my RHR didn’t go below 85 in the gym and during exercise it would routinely hit about 130 from deadlifting/rack pulls (was really emphasising lower back today, the pump was fucking insane!), so bad that a light 315 felt like 405+!)… that and my grip tends to give out completely after a while, so I’m going to invest in some straps (I have tiny, TINY hands)

100bpm at rest could indicate IST or perhaps cardiac dysfunction (have you had an echo?) have you looked into that (if not aggravated from orthostatic positioning), however HR is genetic, some legitimately have a RHR of 100BPM and that’s normal for them, it’s rare, but it happens.

If you’re using coke atm I’d advise staying away from AAS at cyclic dosages. Cocaine will further overload you’re sympathetic nervous system with excess catecholamines, make the heart beat very hard (inducing ischemia leading to cardiomyopathy over the long term), inhibition of potassium channels, increased calcium channel current etc (more mechanisms but these primarily come to mind) induce a profoundly pro-arrythmiac state, not good for someone on AAS at all. Furthermore , combined with alcohol, cocaine forms cocethylene, longer half life, even more toxic. Then there’s the scary reports of cocaine induced leukoencephalopathy, however that’s like saying you’ll acquire cannabinoid hyperemesis syndrome from smoking a joint… then again a single tab of MDMA screwed you over royally for ten years… soooooooo… None of these substances are without risk, by using you’re accepting (as an adult hopefully) the risks and deciding the concept of experimentation is worth it.

Personally I’d never use cocaine (that’s just me) because I don’t see the appeal behind a drug that lasts like an hour at most then crushes the bodies ability to respond to dopamine making you feel suuuuppppper shit afterwards. I’d rather try psychedelics and/or disassociates

Alcohol doesn’t allow you to be you’re “real” self… trust me, you think you’re doing so well, everything is great, then you see what you’re demeanour is like on video… it’s sloppy, incoherent, loud etc. It may amplify personality traits to the extreme, however the profound sense of inebriation, cognitive dysfunction and impaired fine motor skills that come with it kind of nullify this point. I rarely drink at this point, and I noticed when I stopped drinking at parties how irritating it was to be around drunk kids, it’s fun when you’re one of the inebriated, but when you’re not and you’re around a bunch of drunk kids you realise “Jesus Christ, I get like this… what the fuck is wrong with me”. Not too say I don’t drink to excess ever… just rarely (I mean, I’m going to Europe on holiday, staying in hostels etc, chances are some incredibly irresponsible adventures will ensue)

People make stupid, STUPID decisions when drunk. Out of all the recreational drug use I’ve witnessed from members of my age demographic, the consequences from alcohol by far outweigh (in an acute setting, and perhaps even chronically) any other consequence from other substance abuse I’ve seen. Fights, unprotected sex, injuries, dangerous driving/decisions, fucking up friendships, respiratory failure requiring immediate hospitalisation and more… I much prefer weed, no one throws glass bottles at me when stoned or tries to start physical altercations with me for no reason other than to pick a fight with a muscular guy (no I don’t reciprocate, there’s no point, and it has the potential to land me in a world of trouble, I try to deflect such situations and only resort to violence if directly attacked and there is no way out)

Oh no, I havent touched a recreational drug since hppd onset 10 years ago lol. I couldn’t touch any of those including amphetamines(im too scared to try).
I did however order some moda recently to see what happens. My old psych had me on phentermine for a bit, but I didn’t like it, very dirty feeling. 120mg of caffine pushes it for me. Idk caffines effect on glutamate but Jesus. This whole time I forgot I had hppd because I was trying to deal with the anxiety which keeps all the hppd at bay, doing so I made norepinephrine my enemy.

But yeah I really want trt to work just struggling a little with the anxiety/feeling on edge, do you have any advice knowing what you know about my situation? Current protocol is 175mg a week, no hcg no ai, mind you ik this is a high cruise dosage, but I wanna push it a bit because part of trt for me is the hope of gains.
Also from your big post, could you conclude any positive of negative effects trt might have on my condition? Thanks again by the way, dr sir picked a good man on stand by

I appreciate the compliment, but Dr Sir didn’t pick me for stand by. You know I’m merely a child right? (18 years old)

well where does this get you too in relation to labs, for me this dose would equate to about 900ng/dl with top range free T.

Sympathetic nervous system upregulation, in vitro testosterone is demonstrated (at retarded concentrations) to reduce glutamate induce neurotoxicity, though estradiol significantly reduces said effect at same concentrations (another reason not to use AI if this is relevant to real life, can’t see one getting a blood concentration of 10 micro molar, then again T concentrations are expressed differently within different tissues, hence I have no idea how much noe would have to inject to expose neuronal cells to 10 micromoolar (concentration) of T, probably a metric fuckton though.

I’d suggest getting the high RHR checked out, autonomic dysfunction can be treated and ease much discomfort. How much do you exercise? Do you meditate and/or perform yoga, such activities can be wondrous for parasympathetic nervous system recovery. Then there’s supplementation, I’m not going to recommend supplements, you can do the research as I’m uncomfortable doing so. Zinc supplementation can increase glutamate (mechanism via NDMA receptor inhibition if I recall), look up taurine, that’s all the advice I’m comfortable giving… Not telling you to use anything, I don’t want to be responsible for any potential adverse effect.

I wish you all the best and I’m sorry to hear about you’re struggles, I really do sympathise with you but I’m not comfortable dispensing advice in relation to medication, I merely stand here for advice in relation to harm minimisation.

I appreciate it, yeah I forgot to mention I was having chest pains and the elevated rhr made me see my cardiologyst. I got a 48 hr holter monitor, that was good as was ekg… I pushed for echocardiogram and stress test but he kinda said if these looked fine so would those most likely… Main reason I went was after my first week of injections of a high dose for me (375mg failed front load) i had heart palps like crazy so i went to check my heart.

I began more supplementation for my heart so dw about that part. I am a bit curious about beta blockers but after reading about their effects idk… I do a powerbuilding program rn about 5x a week, 1 mile of HIIT every other day, I used to do meditation daily no yoga, and havent really been able to since entering this anxious state

You get first generation beta blockers and second generation (cardioselective) beta blockers

First generation binds to beta 1 and beta 2 adrenergic receptors, to reduce HR beta 1 adrenergic receptor blockade is all that’s really needed and isn’t typically associated with traditional BB sides like shortness of breath, extreme fatigue, exercise intolerance etc. yes, they can fuck you’re glucose tolerance and have the potential for side effects, but I’ve never noticed any SAEs from them, that’s just me though, you may be different.

The only way to know is (if a doctor is willing to give them to you) give them a shot. For all around anxiety a first gen BB is probably best to reduce shakiness/tremors socializing and whatnot but I even find atenolol to be of tremendous help in relation to aiding social interaction

I can get them but I’m gonna research a couple things first… I’m thinking of getting off my ssri and getting on lamotrigine (anti convulsant), so funny to read all the symptoms of my disease and realize how much it all lines up so well, the consant headachess and halos around lights, it has a lot to do with migraine auras etc.

Also as for my labs, the ones I have so far are inaccurate… Gonna need to wait a couple more weeks for this protocol to stick… I have a log for my trt in the trt section if you’re interested in the labs. I’ll be updating when I get more. This anxiety sucks and figuring it out is hard as it makes my symptoms worse.

These are interesting cases

Lamotrigine used for hppd/vs, blocks glutamate etc. Better than using benzos


Dunno if you care @unreal24278 but this is actually pretty interesting. No wonder when women become “estrogen dominant” during/after hormonal spikes, pregnancy, birthcontrol, etc any major hormonal changes that involve estrogen dominance over progesterone, they become more anxious and their sense of smell and what not changes etc.

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@physioLojik I’m curious regarding the history revolving testosterone suspended in carrier oils, such as Nebido, specifically with regards to why it is that it — or gels/creams — are offered as the only source of treatment for men with an androgen deficiency (as a corollary, the only treatment offered to women suffering gender dysphoria, as well) in some countries when it’s an inferior form of treatment when compared to more frequent, self-administered, sub-q injections?

In particular, while I’d imagine that big pharma, inherent friction in large organisations, and dated legislation all come into play, I cannot reconcile wanting to be a caregiver, i.e. a doctor, with accepting inferior forms of treatments for one’s patients. And I just wanted to know what your view is on the topic.

He’s gone bro.

Oh, that’s what I get for not following along v_v

didnt see why, any idea?

He moved, started a new practice I believe and life got busy. I think @unreal24278 had the last correspondence with him. He was a good dude and hopefully will be back. He corrected a lot of misinformation on here.

Unreal is now the master of this forum.

When his experience catches up to his intelligence he will be unstoppable!

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