@Graemsay 100%.
1 Like
I did IR for 3 weeks 1 month the labs. is this not enough cushion time?
what dosage do you recommend T4 and T3, I rather go for the synthetic one. its better and more reliable AFAIKā¦
thanks
This I can not comment on.
1 month I think your thyroid should stabilize
how soon after I get through with post cycle can I have blood work done to see how well I recovered ? last pin will be april 21st gonna start post cycle protocol nolvadex 40/40/20/20 starting may 6th ending june 2nd.
Ye but with longer estered test, the hormonal fluctuation between e3.5d, EOD or ED shots is minimal. The issues these individuals are experiencing are 99% of the time not E2 related at all anyway, thus itās just irritating to see the ED protocol for TEST CYP being parroted for everyone with a small issue to tryā¦ Whatās next? Testosterone undecanoate twice per day (injectable), but not once per day, as the 10ng/dl fluctuation in total testosterone levels might be too much for us to handle!
Iāve done it with TNE and PROP. before, however we are talking about limited periods of time though, purely for experimentation (and at TRT doses). I wouldnāt want to stick myself with test prop/TNE for the rest of my life, itās a pain and unnecessary.
I thought DHT also (along with oestrogen) played a large role in NO production? Low libido from hypogonadism isnāt just caused from a deficiency in oestrogen, thus deficiency in serotonin and NO (at least thatās what I think). Testosterone and Dihydrotestosterone themselves have profound neurologic impacts, and are thus also going to be somewhat responsible for neurotransmitter balance. (am I wrong)
Hey, are you telling me my daily dose of methamphetamine (four days on, three days off) could be causing me to feel shitty? Was almost sure it was estrogen. You see I take my meth for four days, then feel terrible for the next three days. However if I take some exemestane on the fifth and sixth day I feel fineā¦ BUT, I mixed up the bottles for desoxyn and exemestane.
The above paragraph is a jokeā¦ obviouslyā¦ The meth is actually diacetylmorphineā¦ pffft wouldnāt mess around with any of the hard stuff
(edit, just making sure everyone knows I am kidding around)
1 Like
Thanks @physioLojik - Iāll get back to you after my consult with Defy because that consult is already paid for.
Based on lab work above, you clearly donāt think my E2, Prolactin or Testosterone are something to worry about. Itās more of a neurotransmitter issue . Correct? E2 = 66 is obviously much higher than oft-mentioned e2=22pg/ml goal but in your messages youāve talked about your patients with over 100 E2 and no ED problems. So, I donāt need to worry about adjustment to TRT protocol.
I should add - if this is indeed a neurotransmitter problem, why did it just happen in the last 2 months or so? I mean, I have had ED for past 2 years or so but it is inconsistent and always fixed with a 5mg Cialis. But now days even Cialis 25mg (5 times my normal dosage) doesnāt work. So, if it was a neurotransmitter issue, wouldnāt I have this problem for past 2 years, not just last 2 months since Iāve been on a consistent TRT protocol?
This is why I keep suspecting that this might be a cardiovascular problem - maybe my arteries were a little clogged with cholesterol 2 years ago and gradually they have become so much more clogged that even 25mg Cialis is not enough to relax them to allow for blood flow.
Iām really worried it might be close to arteriosclerosis and that scares me because there is no effective way to reverse that condition. I read a lot of studies and it looks like 2+ years of high dose statin can reverse it but only 100th of a mm, not by much. So, if my arteries that carry blood to penis are blocked, no amount of dopamine, nitric oxide, seretonin is going to fix it and no amount of statin drug is going to reverse it. That is what worries and scares me!
I want to add:
- Iām not fat or overweight. 5ā10, 155lbs, never been over 162 lbs.
- Reasonably clean diet for past 6 months
- Workout 2 to 3x a week
- 8 months ago diagnosed with hypothyroidism (hairloss, insomnia and brain fog were my symptoms) and thats when I first started seeing endocrinologist and was subsequently diagnosed with low T and was put on TRT, prediabetic and was put on low-dose Metformin as a precuation to prevent diabetes and high cholestrol and was put on Crestor for it.
I was admittedly on a poor junk food diet for about 2 years but I ate only one or 2 meals a day so I never got fat, never consumed calorie surplus, I guess. But since 8 months ago I was diagonsed with so much shit, I made lifestyle changes and been living a reasonably healthy lifestyle. Can be improved further but it is several times better lifestyle than before.
I donāt think 2 years of bad cholesterol will give you plaque.
Wife recently had a ct cardic angiogram. You can get this test if insurance covers it. It checks for plaque build up and gives a calcium score .
Dr chaNged her from zocor to crestor because she had 25% plaque in a artery. I read also that lipitor and crestor are only 2 statins that can reverse plaque. Key I read was ldl being below 70.
For when I had low e2 nothing could get my dick up. No medication. Many times I thought I had high e2 and it was low.
You can also get a contrast abdominal ct that will check for arteialsclorosis south of your heart.
Thanks @charlie12 - Iāll privately pay for it and get it done. At the moment, no insurance.
For the abdomen and pelvis CT I drank a contrast AND they also did IV. They saw every organ and blood vessels. Even prostate. Colon. All intestines.
Youāre super overthinking this.
UPDATE - just had my consult with Defy Medical. Here are the adjustments:
They switched me to cream and weād have a follow-up in 4 weeks:
-
Testosterone 20% cream. 2 clicks to start with. Upto 3 clicks. Didnāt say need to apply on scrotum but if I wanted to, they said, half of one click would be sufficient for scrotum and the remaining to be applied over body - shoulder, chest, waist whatever.
(they said, my DHT is in lower half and cream should help increase it - that should help with libido; and they said that because I am naturally low SHBG, daily application of cream is preferable to twice a week shots) -
Upped my HCG to 500 IU twice a week (instead of 250 IU twice a week)
-
AI Anastrazole .125mg only if needed
So, Iāll be on this protocol for 4 weeks and see how it goes if libido and erections come back.
If your DHT is low, you should consider Masteron.
What do you think about this dht level? Would masteron cause benefit at these levels? @studhammer
Hey brother,
I donāt know. It seems on the low end of the range. I know you saw my post about the fast effects Iām already seeing on Mast. I didnt get blood work like I should have but I feel like the NPP impacted my DHT and its functions related to erections and libido.
1 Like
Iām really happy that masteron is helping you; npp messed up your serotonin and dopamine. Masteron has very strong affect on dopamine. Just be careful because your body will start to realize an overload and downregulate those receptors.
What would a good long term dose be? Or is there such a thing? @physioLojik
I always thought that once you have saturated a given receptor that it automatically Upregulates those receptors. Why are serotonin and dopamine receptor different?
No thatās not the case at all. The body in its quest for homeostasis will automatically over time downregulate receptors that it views as over-activated. This is a super simplified explanation but easy to understand - this is how tolerances of any kind are built up. Over time when you give your body anything in excess - for instance caffeine - your body starts to desensitize receptors for caffeine and you have limited effects.
If androgen receptors were upregulated upon saturation then you would, given that idea, constantly have unlimited androgen receptor upregulation and in fact increased sensitivity over time. Youād never stop growing from androgens - which we know isnāt true.
In its quest to maintain homeostasis the body will always downregulate receptors which are constantly saturated. I believe I posted a video about this idea in the past.
Donāt confuse regulation with sensitivity either. When you take testosterone you add more androgen receptors - but they also become less sensitive. The body is smarter than you. This is actually similar to insulin sensitivity. When you constantly bombard cells with insulin they stop listening - they become LESS sensitive when MORE hormone is present over time. @alldayeveryday
1 Like
Of masteron? No long term use of that. @studhammer
@physioLojik you donāt sound like a great fan of masteron either.
It sounds like hammering dopamine levels wouldnāt help with depression, or might cause some symptoms. Looks like masteron should be on my avoid list too.