Care to explain? I’ve certainly never heard this. [/quote]
The two peptides have differing (and complex!) amino acid structures. When mixed, the differing amino acids may chemically interact with each other and lead to loss or combination of some of those aminos, leading to degradation.
It is not very clear how long this process takes. Mixing right before injecting is almost universally accepted as good to go (some people still insist on injecting twice–separate syringes for each peptide!). Consensus seems to be that 6-12 hours is starting to push the envelope, especially if the mixture is not refrigerated in the meantime. I personally don’t keep it more than 12.[/quote]
Interesting. Thanks for that, I’ll look into it and possibly adjust my habits just to be sure. Probably will just make sure and load exactly enough for what I will use that day and keep using the same syringe multiple times. Instead of just leaving it and reloading it.
I will also keep in mind that I’m still not convinced that a lot of what read on internet message boards about the degradation of peptides is just bro-knowledge; as I’ve had at least one actual biologist whose field of study was applicable to our discussion tell me that peptides in general are far more hardy than we give them credit for. I can back this us with a little anecdotal experience in that some G2 (which causes me hunger, though not to the same degree as G6), that I had sitting reconstituted in my fridge for close to two months caused all the gut motility and hunger I associate with a freshly reconstituted vial after all that time. You’d think if the peptide were so fragile this would not be the case.
In any case, I appreciate the heads up. I’m interested in pursuing this further, so please feel free to post up any links you have or stumble upon,(though I bet I know which website dat they b leading to and will be checking there shortly myself).
If this is true then it seems to make the most sense to load 2 separate syringes with one peptide in each. And use them separately, multiple times. Unless you dont like reusing needles, even for subq shots, then combining works. [/quote]
That’s true but requires sticking yourself twice each time you take a dose. At 3 doses a day, you’re looking at 6 jabs. Not a huge deal, but the track marks start to add up even with insulin pins.
Its a trade off. I’ve grown comfortable with the slightly arbitrary 12 hours and don’t feel that it loses its effect after that time. I will load 3 doses into one pin after my workout at around 8 pm, take another dose before bed, then empty it before breakfast around 8 am.
[quote]Cortes wrote:
I will also keep in mind that I’m still not convinced that a lot of what read on internet message boards about the degradation of peptides is just bro-knowledge; as I’ve had at least one actual biologist whose field of study was applicable to our discussion tell me that peptides in general are far more hardy than we give them credit for. I can back this us with a little anecdotal experience in that some G2 (which causes me hunger, though not to the same degree as G6), that I had sitting reconstituted in my fridge for close to two months caused all the gut motility and hunger I associate with a freshly reconstituted vial after all that time. You’d think if the peptide were so fragile this would not be the case. [/quote]
I agree. These chemicals are more resilient than sometimes given credit for, but most of what I said is also based on literature that accompanies these pharm grade peptides. These are the ones used in the well regarded research studies.
I agree that the timelines given are probably a bit conservative, just like all things medicine. Ever seen the expiration date on a pill of aspirin? Is there any doubt in your mind that it will be just as effective past that expiration date? I imagine the peptides are the same way–“guaranteed” up to a certain point, but after that all bets are off and use at your own discretion.
so guys i’ve been having trouble feeling the sides from G6.
took a 500mcg dose earlier today. no hunger, a bit of light headed-ness but that could be due to taking the shot right after waking up from a nap then walking out…
i’d hate to throw it all away after spending the money on it but the only thing i can think of that’s wrong with it would be tht the first 10 days after i got it, it was kept at room temp.
any of the more knowledgeable guys have any insight? thanks
"A common misconception is that since a peptide is a short protein, it is as unstable as protein. The truth is that peptide is much more stable than protein because the two factors affect protein stability do not exist for synthetic peptides. These two factors are the tertiary folding and proteinase contamination.
Due to their short length, most peptides do not have tertiary structure. The tertiary structure is unstable because it is held together by non-covalent bonds such as electrostatic interaction. Therefore, peptide can not be denatured. Under this assumption, a peptide can only be damaged by covalent modification or break of peptide bonds. Unlike protein purified from cells that are full of various proteinase, the chance of proteinase contamination is extremely small for a synthetic peptide. Reactions could damage peptide such as oxidation require high or low pH. They are very slow under the neutral pH condition that most biological experiments are performed. Bacteria contamination is probably a more serious threaten than those reactions, because peptide is a good nutrition source for bacteria. Therefore, solvent filtration is important for peptide stability."
Before reconstitution, most peptides, including G6 and even GH, should be completely fine at room temp.
If you are not feeling G6 my guess would be that your source messed up and sent you a different peptide like CJC or maybe something that looks like a peptide like maybe HCG. 500mcg of G6 shot all at once is NOT something you should not be feeling.
Or you got a crap batch of G6. This does happen. Remember we are talking about the production of an unregulated gray-market product manufactured sometimes clandestinely in a Chinese factory, distributed by Chinese businessmen. Kind of scary for all of us, when you start thinking about it that way.
Either way, if you are not getting hunger or gut motility from 500mcg of G6, your supplier has some explaining to do.
Back to your peptide issue, are they plain, unlabeled green or blue top vials, or “research” peptides that have had a label slapped on them to make it seem as if the research chem place is actually synthesizing the peps themselves (they aren’t)? Doubt this will lead anywhere, just curious.
[quote]Cortes wrote:
Thanks for the info and the link, Lurxalot.
Back to your peptide issue, are they plain, unlabeled green or blue top vials, or “research” peptides that have had a label slapped on them to make it seem as if the research chem place is actually synthesizing the peps themselves (they aren’t)? Doubt this will lead anywhere, just curious.[/quote]
well i bought ghrp6 and mod grf at the same time, came in the same package but each is labeled ghrp6 or mod grf.
I figured it would be legit
edit: what do you think about trying a 400 mcg dose from each of the remaining G6 viles to see if i get a reaction (seperately of course)/ if they luckily happen to be good?
Only way I could think of to reliably ascertain whether your vial contains this peptide or that one is with a lab test (unless it’s melanotan, haha), but G6 should stimulate some hunger, at least.
I am getting the impression this is your first run with G6, as, if you have ever experienced the true G6 hunger, you’d KNOW something was up when you got the kind of (non-)reaction you are describing here.
I don’t think there are too many who will disagree with me when I say that there is nothing, not one thing, that compares to that feeling. It is utterly unique, and I don’t give a damn who you are, there is no way in hell you could ever exercise any sort of will power once it has set in.
So when I hear you are not getting ANYTHING out of it…? Like I said, I’d be having some words with my supplier immediately.
500mcg of g6 would give me anxiety purely because I cant chew fast enough to curb the hunger.
I shot 400 by accident when I thought I was doing 200 and then had to take a car ride to the buffet, I was sweating becuase of how uncomfortable that feeling is when theres no food around.
The sad truth is that right now, theres some shit going down regarding these peptides. Its hit or miss if youre ordering from research chem sites. At the moment, at least. I dont know this first hand, I picked up on it reading other forums.
ok so gonna put in an order to a more trusted source… question though.
mianly only started G6/GRF bc i knew i was gonna do my first cycle soon. today is day 16 into a front loaded test e cycle, would i be better off with HGH-frag than giving the G6/GRF combo a couple weeks to raise IGF levels?
I don’t know alot about HGH-frag, but everything that I have heard about it has suggested it is worthless.
GHRP/GRF is a fantastic stack. Only thing I have found to compare is actual exogenous GH. That’s why I just get both and use them together. >;)
I’ve already said it a thousand times, but if you are getting your PEDs from a UGL or “research” place, you HAVE NO IDEA what you are buying and putting into your body! Unless a site provides regular, verifiable lab reports on their products, you are just playing craps with your money and your health.
Not that purchasing it directly from China or Hong Kong is so much more reliable, but at least you have one less potential charlatan between you and your drugs, and the Chinese suppliers are often big enough that they need to at least produce the product they are claiming to offer.
ok, ill stick with G6/GRF combo then… i didnt mean to sound like i was blowing off your warning about not knowing what i’m really using, though. the research site i was planning on ordering from i’ve heard first hand their stuff is legit
It was sarcastically pointed out above, but The Grammar Nazi is uncertain you understood the joke.
“Welp,” is a word used by rednecks to excuse themselves from a conversation. [/quote]
as in “welp I gots to go get me a peice of mah sista”
that kinda welp?
It was sarcastically pointed out above, but The Grammar Nazi is uncertain you understood the joke.
“Welp,” is a word used by rednecks to excuse themselves from a conversation. [/quote]
as in “welp I gots to go get me a peice of mah sista”
that kinda welp? [/quote]
i asked before hand on another board or maybe this one and i was told it was good to use…[/quote]
Same thing I use. Filtered through a .22um whatman first, of course.
You are actually ahead of the curve in that regard. I chuckle at the smart folks selling ice to Eskimos in the form of a $30 bottle of “Pharmaceutical Grade Sodium Chloride Solution for Injection,” which is, yeah, the same $3 bottle of contact lens solution probably half the guys purchasing it already have in their house in the bathroom cabinet.
Welp, just thought I’d give an update. I ran out of CJC two days ago and have just been using the G 6. It looks like the CJC was the culprit, I have had no issues with skin irritation or itching. I also upped my dose of G 6 with no issues. I was wondering though about the hunger. I was using 100mcg 3x a day of both G 6 and CJC. I experienced no hunger with that dose. I have upped my G 6 to 250mcg 3x a day also with no hunger at all. I was doubting the quality of my product after reading some of these posts, however I am getting extreme numbness and tingling in the hands through out the day and when I wake up in the morning my hands feel like rocks and I have to shake them out for a while to get the feeling back.
[quote]inkcreep wrote:
Welp, just thought I’d give an update. I ran out of CJC two days ago and have just been using the G 6. It looks like the CJC was the culprit, I have had no issues with skin irritation or itching. I also upped my dose of G 6 with no issues. I was wondering though about the hunger. I was using 100mcg 3x a day of both G 6 and CJC. I experienced no hunger with that dose. I have upped my G 6 to 250mcg 3x a day also with no hunger at all. I was doubting the quality of my product after reading some of these posts, however I am getting extreme numbness and tingling in the hands through out the day and when I wake up in the morning my hands feel like rocks and I have to shake them out for a while to get the feeling back. [/quote]