I have seen Serotonin and Dopamine blood tests at my lab but never done them nor understand if they are useful so perhaps some other more experienced members can shed some light? I’m also a high SHBG guy with a crashed cFT before starting TRT. But even with crashed barely in range cFT I never had ED/libido problems unless I was underfed/overdieted. Now the thing with FT is that nobody knows where you need your FT level for best/optimal symptom resolution. Some do better in lower range, some do better in higher range. My guess is that you will feel worse by increasing your dose as you already said you are feeling the worst since starting and increasing your dose. ED/libido is multifactorial, as you probably already know. If you are pinning 160mg split E3.5D thats def not a small dose in the realms of real TRT and not sports TRT, if that makes sense. I’m interested how your story will unfold but don’t rule out the situation that too high of the FT level gives you less symtom relief that lower levels. It’s not that simple and not that easy. Forums are filled with guys running higher dosages and struggling with ED/libido issues FWIW. So it always pays to think outside the box, experiment with dosages and give it time, as this stuff really takes time. And yet TRT is not a magic bullet, it might help or it might make it worse and it’s only for you to find out. Hope you feel better soon. Hang in there.
Merry Christmas!
