25 Y/O - 8 weeks into TRT. AI Added to protocol. Updates below

Your E2 was too high, target is 22pg/ml - 80 pmol/L

You did not describe clomid dose [that I saw].

Clomid increases LH/FSH but if too much, T–>E2 inside the testes can become high and serum E2 gets too high.

your 39.9 and 38.4 are what?
We need labs clearly posted with lab ranges.
You posted free T?

Your T levels were near or below expected TRT levels, so you numbers strongly suggest that anastrozole will be needed. Your doc is not preemptively going after E2 management.

With TRT T+hCG, you are getting T from injections and a smaller amount of hCG should be used to preserve testes and ferility. 1200iu/week is expensive and may create high T–>E2 inside the testes, that anastrozole cannot correct.

Your E2 levels were high enough to spoil the game.

Suggest:

  • self inject 50mg T twice a week, subq, not IM, with #29 1/2" 0.5ml insulin syringes
  • 0.5mg anastrozole at time of T injections
  • 250iu hCG subq EOD

A few are anastrozole over-responders who will crash E2 on typical dosing, they need 1/4th the expected dose and should stop for 5-6 days then resume at the lower dose if suspected.

TSH should be near 1.0, 3.15 is way too high, the ranges are stupid. fT4 is a bit shy of mid-range. fT3 should be near or a bit about mid-range. fT3=5.2 is insane. I suspect that elevated rT3, reverse T3 is blocking fT3. I really need you to check your oral body temperatures as per below. If low that strongly suggests elevate rT3 can can be a result of stress or training with low-T and low thyroid function where young men replace that lost natural energy with adrenaline. Please see the thyroid basics stick for references to rT3, stress, illnesses, accidents, surgeries, over-training, adrenal fatigue, AM cortisol and Wilson’s book ‘adrenal fatigue’.


Please read the stickies found here: About the T Replacement Category - #2 by KSman

  • advice for new guys - need more info about you
  • things that damage your hormones
  • protocol for injections
  • finding a TRT doc

Evaluate your overall thyroid function by checking oral body temperatures as per the thyroid basics sticky. Thyroid hormone fT3 is what gets the job done and it regulates mitochondrial activity, the source of ATP which is the universal currency of cellular energy. This is part of the body’s temperature control loop. This can get messed up if you are iodine deficient. In many countries, you need to be using iodized salt. Other countries add iodine to dairy or bread.

KSman is simply a regular member on this site. Nothing more other than highly active.

I can be a bit abrupt in my replies and recommendations. I have a lot of ground to cover as this forum has become much more active in the last two years. I can’t follow threads that go deep over time. You need to respond to all of my points and requests as soon as possible before you fall off of my radar. The worse problems are guys who ignore issues re thyroid, body temperatures, history of iodized salt. Please do not piss people off saying that lab results are normal, we need lab number and ranges.

The value that you get out of this process and forum depends on your effort and performance. The bulk of your learning is reading/studying the suggested stickies.