TSH should be closer to 1.0
T4 is well below mid-range
This may be from not using iodize salt. Iodine is essential for thyroid hormone production.
fT3 is the only active thyroid hormone and should be tested. There is no T4 receptor.
Do you get cold easily?
Are outer eyebrows getting sparse?
Low thyroid function has most of the same effects as low T.
Please see ‘oral body temperatures’ below to further assess this.
SHBG is too high, perhaps from elevated E2.
Prolactin opposes dopamine production which can rob one of ability to enjoy or feel reward - result can be depression.
While an adinoma was not detected and imaging method may not have been optimal, you should ask for a trial of 0.25mg Dostinex/cabergoline twice a week for a month or so to access how this has been affecting your HPTA and mental state. If things improve, you have a diagnosis and treatment in one stroke.
Prolactin can be elevated by recent orgasm or cuddling {puppies | kittens | babies} - so avoid for a few days prior to labs.
Low dopamine can cause increased prolactin, they move in opposite directions. Your stimulants may have worn down your dopamine production and that is also the measure of what addictive drugs do via excess dopamine activity.
E2 levels can be increased by more production or reduced liver clearance. AST is high. ALT/AST can be increased by recent training and sore/injured muscles. - avoid
Higher SHBG can inflate TT with non-bioavailable T+SHBG so TT overstates your T status. Your
bio-available are low relative to your TT.
Some liver problems can increase SHBG in the liver.
Please read the stickies found here: About the T Replacement Category - #2 by KSman
- advice for new guys - need more info about you
- things that damage your hormones
- protocol for injections
- finding a TRT doc
Evaluate your overall thyroid function by checking oral body temperatures as per the thyroid basics sticky. Thyroid hormone fT3 is what gets the job done and it regulates mitochondrial activity, the source of ATP which is the universal currency of cellular energy. This is part of the body’s temperature control loop. This can get messed up if you are iodine deficient. In many countries, you need to be using iodized salt. Other countries add iodine to dairy or bread.
KSman is simply a regular member on this site. Nothing more other than highly active.
I can be a bit abrupt in my replies and recommendations. I have a lot of ground to cover as this forum has become much more active in the last two years. I can’t follow threads that go deep over time. You need to respond to all of my points and requests as soon as possible before you fall off of my radar. The worse problems are guys who ignore issues re thyroid, body temperatures, history of iodized salt. Please do not piss people off saying that lab results are normal, we need lab number and ranges.
The value that you get out of this process and forum depends on your effort and performance. The bulk of your learning is reading/studying the suggested stickies.