1 Year Into TRT, Not Pleased with Recent Lab Work, Please Advise

Please see these links found here: About the T Replacement Category - #2 by KSman

  • advice for new guys
  • things that damage your hormones
  • protocol for injections
  • finding a TRT doc

The above is a lot of reading. You will know more than your doc. Good that he is working with you. His resistance to anastrozole is silly. It is an aromatase inhibitor used in a TRT context to modulate E2 levels.

E2=74 suggests a possible liver issue in that the liver is not clearing E2 properly. And we would then expect the liver to produce more SHBG to scavenge E2, but SHBG is low; again pointing to the liver.

Some medical conditions can lower SHBG, but your labs are very narrow.

Take 0.5mg anastrozole at time of injections. This is 1mg/week and more cost effective than Exemestane - Wikipedia while been a lower drug load on the body. In any case, you adjust dosing to get desired E2 levels and I suggest E2=22pg/ml.

You can inject 250iu hCG SC EOD

Labs:
TT
FT
E2
LH/FSH should have been done before any TRT was started
prolactin - one time, do not have sex for 48 hours and do not cuddle babies or puppies
CBC
hematocrit
TSH
fT3
fT4 [please not T3, T4]
fasting cholesterol
fasting glucose
AST/ALT
AM cortisol [at 8AM please]

Energy can be affected by thyroid.
Have you been using iodized salt to support thyroid hormone production?
Do you get cold easily?
Outer eyebrows sparse?
Generalized hair thinning?